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List of purification methods in chemistry From Wikipedia, the free encyclopedia This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.
July Learn how and when to remove this template message Purification in a chemical context is the physical separation of a chemical substance of interest from foreign or contaminating substances. Pure results of a successful purification process are termed isolate.
The following list of chemical purification methods should not be considered exhaustive. Affinity purification purifies proteins by retaining them on a column through their affinity to antibodiesenzymesor receptors that have been immobilised on the column.
Filtration is a mechanical method to separate solids from liquids or gases by passing the feed stream through a porous sheet such as a cloth or membrane, which retains the solids and allows the liquid to pass through.
Centrifugation is a process that uses an electric motor to spin a vessel of fluid at high speed to make heavier components settle to the bottom of the vessel.
Evaporation removes volatile liquids from non-volatile soluteswhich cannot be done through filtration due to the small size of the substances. Liquid—liquid extraction removes an impurity or recovers a desired product by dissolving the crude material in a solvent in which other components of the feed material are soluble.
Crystallization separates a product from a liquid feed stream, often in extremely pure form, by cooling the feed stream or adding precipitants that lower the solubility of the desired product so that it forms crystals.
The pure solid crystals are then separated from the remaining liquor by filtration or centrifugation. In analytical and synthetic chemistry work, purchased reagents of doubtful purity may be recrystallized, e.
Adsorption removes a soluble impurity from a feed stream by trapping it on the surface of a solid material, such as activated carbonthat forms strong non-covalent chemical bonds with the impurity.
Chromatography employs adsorption and desorption on a packed bed of a solid to purify multiple components of a single feed stream.
Smelting produces metals from raw oreand involves adding chemicals to the ore and heating it up to the melting point of the metal.
Refining is used primarily in the petroleum industry, whereby crude oil is heated and separated into stages according to the condensation points of the various elements. Distillationwidely used in petroleum refining and in purification of ethanol separates volatile liquids on the basis of their relative volatilities.
Distillation are of different types Simple distillation,steam distillation etc. Water purification combines a number of methods to produce potable or drinking water.
Downstream processing refers to purification of chemicals, pharmaceuticals and food ingredients produced by fermentation or synthesized by plant and animal tissues, for example antibioticscitric acidvitamin Eand insulin.
Fractionation refers to a purification strategy in which some relatively inefficient purification method is repeatedly applied to isolate the desired substance in progressively greater purity.
Electrolysis refers to the breakdown of substances using an electric current. This removes impurities in a substance that an electric current is run through Sublimation is the process of changing of any substance usually on heating from a solid to a gas or from gas to a solid without passing through liquid phase.
Bioleaching is the extraction of metals from their ores through the use of living organisms. Sublimation Sublimation is the direct change of a solid to vapor on heating without going through its liquid state and is used to separate volatile organic compounds from non volatile mainly inorganic compounds.Separation Techniques witnessed an amalgamation of peerless speakers who enlightened the crowd with their knowledge and confabulated on various topics related to the field of Separation Techniques.
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Separation and purification - Chromatography: Chromatography, as noted above, is a separation process involving two phases, one stationary and the other mobile.
Typically, the stationary phase is a porous solid (e.g., glass, silica, or alumina) that is packed into a glass or metal tube or that constitutes the walls of an open-tube capillary. Organic Chemistry Frontiers.
The international, high impact journal for cutting-edge researches from all disciplines of organic chemistry. We were going to call this tutorial "Reverse Phase HPLC for Proteomics" but we decided to exercise some restraint.
We decided to write this tutorial because reverse phase chromatography is the most common form of chromatography used in LC/MS applications.